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They also tend to become cold more quickly because their thermal regulation changes as their fat burning capacity slows and their primary body temperature drops. Fontana says as calorie restriction research advancements on many fronts, it’s becoming obvious that dietary advice once based on epidemiological data right now is practical from a molecular point of view. In the past, dietitians might recommend more fruit and veggies or less meats and more whole grains. They based that suggestions on studies showing individuals who ate even more vegetables or fewer animal items tended to have less cardiovascular disease. ‘We now have transferred from epidemiology to molecular biology,’ he says. ‘We realize that certain nutrients, and also lower calorie intake, can impact IGF-1 and other pathways.